What sizes are available for Anti-FXR2 Antibody Picoband® Fluoro594 Conjugated?

Anti-FXR2 Antibody Picoband® Fluoro594 Conjugated is available in the following size(s): 100 µg/Vial.

Is Anti-FXR2 Antibody Picoband® Fluoro594 Conjugated in stock?

Anti-FXR2 Antibody Picoband® Fluoro594 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

Anti-FXR2 Antibody Picoband® Fluoro594 Conjugated

Q: What is the catalog number for Anti-FXR2 Antibody Picoband® Fluoro594 Conjugated?

The catalog number for Anti-FXR2 Antibody Picoband® Fluoro594 Conjugated is A05130-4-Fluoro594.

Selected Variant

A05130-4-Fluoro594

Size: 100 µg/Vial

Product Specifications

Background

Fragile X mental retardation syndrome-related protein 2 is a protein that in humans is encoded by the FXR2 gene. The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome.

Synonyms

Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1; SLC6A1; GABATR, GABT1, GAT1

Gene Name

FXR2

Gene ID

9513

UniProt

P51116

Host

Rabbit

Reactivity

Human, Monkey, Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human FXR2 recombinant protein (Position: N153-K651) .

Clonality

Polyclonal

Tissue Specificity

Expressed in many tissues, highest levels in skeletal muscle.

Applications

Flow Cytometry

Field of Research

Neuroscience, Neurotransmitter, Transporters

Purification

Immunogen affinity purified.

Form

Liquid

Function

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

References & Citations

1. Bontekoe, C. J. M., McIlwain, K. L., Nieuwenhuizen, I. M., Yuva-Paylor, L. A., Nellis, A., Willemsen, R., Fang, Z., Kirkpatrick, L., Bakker, C. E., McAninch, R., Cheng, N. C., Merriweather, M., Hoogeveen, A. T., Nelson, D., Paylor, R., Oostra, B. A. Knockout mouse model for Fxr2: a model for mental retardation. Hum. Molec. Genet. 11: 487-498, 2002. 2. Darnell, J. C., Fraser, C. E., Mostovetsky, O., Darnell, R. B. Discrimination of common and unique RNA-binding activities among fragile X mental retardation protein paralogs. Hum. Molec. Genet. 18: 3164-3177, 2009. 3. Kirkpatrick, L. L., McIlwain, K. A., Nelson, D. L. Comparative genomic sequence analysis of the FXR gene family: FMR1, FXR1, and FXR2. Genomics 78: 169-177, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

67074 MW

Applications Notes

Gene Name Synonym

Sodium- and chloride-dependent GABA transporter 1

Subcellular Location

Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity) . .

Protein Name

Long-chain-fatty-acid--CoA ligase 5

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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