Anti-Fanca/FAA Antibody Picoband®

Fanconi anaemia, complementation group A, also known as FAA, FACA and FANCA, is a protein which in humans is encoded by the FANCA gene. Acts upstream of or within several processes, including gonad development; regulation of CD40 signaling pathway; and regulation of regulatory T cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of Fanconi anaemia nuclear complex. Is expressed in several structures, including gut; liver; lung; reproductive system; and spleen. Used to study Fanconi anemia complementation group A. Human ortholog (s) of this gene implicated in several diseases, including Fanconi anemia (multiple) ; acute myeloid leukemia; esophagus squamous cell carcinoma; ovarian disease (multiple) ; and skin melanoma. Orthologous to human FANCA (FA complementation group A) .

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Interacts with MCMBP.

1. Abu-Issa, R., Eichele, G., Youssoufian, H. Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. Blood 94: 818-824, 1999. 2. Bouchlaka, C., Abdelhak, S., Amouri, A., Ben Abid, H., Hadiji, S., Frikha, M., Ben Othman, T., Amri, F., Ayadi, H., Hachicha, M., Rebai, A., Saad, A., Dellagi, K., Tunisian Fanconi Anemia Study Group. Fanconi anemia in Tunisia: high prevalence of group A and identification of new FANCA mutations. J. Hum. Genet. 48: 352-361, 2003. 3. Castella, M., Pujol, R., Callen, E., Trujillo, J. P., Casado, J. A., Gille, H., Lach, F. P., Auerbach, A. D., Schindler, D., Benitez, J., Porto, B., Ferro, T., and 20 others. Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations. Blood 117: 3759-3769, 2011.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.