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Anti-CRABP2 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Cellular retinoic acid-binding protein 2 is a cytoplasmic binding protein that in humans is encoded by the CRABP2 gene. This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Synonyms

Myelin-oligodendrocyte glycoprotein; MOG

Gene Name

CRABP2

Gene ID

1382

UniProt

P29373

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human CRABP2 recombinant protein (Position: R60-D117) .

Clonality

Polyclonal

Tissue Specificity

Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

Applications

Flow Cytometry

Field of Research

Cancer, Lipid Metabolism, Metabolism, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Mediates homophilic cell-cell adhesion (By similarity) . Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Acts as a receptor for rubella virus.

References & Citations

1. Elder, J. T., Astrom, A., Pettersson, U., Voorhees, J. J., Trent, J. M. Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization. Hum. Genet. 89: 487-490, 1992. 2. Flagiello, D., Apiou, F., Gibaud, A., Poupon, M. F., Dutrillaux, B., Malfoy, B. Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization. Cytogenet. Cell Genet. 76: 17-18, 1997. 3. Giguere, V., Lyn, S., Yip, P., Siu, C.-H., Amin, S. Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein. Proc. Nat. Acad. Sci. 87: 6233-6237, 1990.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Myelin oligodendrocyte glycoprotein

Subcellular Location

Cell membrane. Multi-pass membrane protein. Single-pass type I membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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