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Anti-ALYREF Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Aly/REF export factor, also known as THO complex subunit 4 is a protein that in humans is encoded by the ALYREF gene. The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.

Synonyms

Segment polarity protein dishevelled homolog DVL-3; Dishevelled-3; DSH homolog 3; DVL3; KIAA0208

Gene Name

ALYREF

Gene ID

10189

UniProt

Q86V81

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human ALYREF recombinant protein (Position: M1-S257) .

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Cardiogenesis, Cardiovascular, Cytoplasmic, Neurogenesis, Neurology Process, Neuroscience, Signaling Pathways, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

May play a role in the signal transduction pathway mediated by multiple Wnt genes.

References & Citations

1. Bruhn, L., Munnerlyn, A., Grosschedl, R. ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCR-alpha enhancer function. Genes Dev. 11: 640-653, 1997. 2. Luo, M.-J., Zhou, Z., Magni, K., Christoforides, C., Rappsilber, J., Mann, M., Reed, R. Pre-mRNA splicing and mRNA export linked by interactions between UAP56 and Aly. Nature 413: 644-647, 2001. 3. Masuda, S., Das, R., Cheng, H., Hurt, E., Dorman, N., Reed, R. Recruitment of the human TREX complex to mRNA during splicing. Genes Dev. 19: 1512-1517, 2005.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

78055 MW

Applications Notes

6

Gene Name Synonym

Segment polarity protein dishevelled homolog DVL-3

Subcellular Location

Cytoplasm .

Protein Name

Segment polarity protein dishevelled homolog DVL-3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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