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Anti-Glycine decarboxylase/GLDC Antibody Picoband® (monoclonal, 3D3D3) Fluoro647 Conjugated

Selected Variant

M04777-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Glycine decarboxylase also known as glycine cleavage system P protein or glycine dehydrogenase is an enzyme that in humans is encoded by the GLDC gene. Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase) . The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH) .

Synonyms

Cofilin-2; Cofilin, muscle isoform; CFL2

Gene Name

GLDC

Gene ID

2731

UniProt

P23378

Host

Mouse

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Glycine decarboxylase/GLDC recombinant protein (Position: K574-S1020) .

Clonality

Monoclonal

Clone

Clone: 3D3D3

Tissue Specificity

Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.

Applications

Flow Cytometry

Field of Research

Cell Adhesion Proteins, Epigenetics and Nuclear Signaling, Integrins, Mediator Complex, Neuroscience, Receptors, Transcription

Purification

Immunogen affinity purified.

Form

Liquid

Function

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere.

References & Citations

1. Alfi, O., Donnell, G. N., Allerdice, P. W., Derencesenyi, A. The 9p- syndrome. Ann. Genet. 19: 11-16, 1976. 2. Applegarth, D. A., Toone, J. R. Nonketotic hyperglycinemia (glycine encephalopathy) : laboratory diagnosis. Molec. Genet. Metab. 74: 139-146, 2001. 3. Bodkin, J. A., Coleman, M. J., Godfrey, L. J., Carvalho, C. M. B., Morgan, C. J., Suckow, R. F., Anderson, T., Ongur, D., Kaufman, M. J., Lewandowski, K. E., Siegel, A. J., Waldstreicher, E., and 19 others. Targeted treatment of individuals with psychosis carrying a copy number variant containing a genomic triplication of the glycine decarboxylase gene. Biol. Psychiat. 86: 523-535, 2019.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Cofilin 2

Subcellular Location

Cytoskeleton. Nucleus matrix.

Isotype

Mouse IgG1

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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