What sizes are available for Anti-TRIM24 Antibody Picoband® (monoclonal, 4G6C2) Fluoro488 Conjugated?

Anti-TRIM24 Antibody Picoband® (monoclonal, 4G6C2) Fluoro488 Conjugated is available in the following size(s): 100 µg/Vial.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

Anti-TRIM24 Antibody Picoband® (monoclonal, 4G6C2) Fluoro488 Conjugated

Q: What is the catalog number for Anti-TRIM24 Antibody Picoband® (monoclonal, 4G6C2) Fluoro488 Conjugated?

The catalog number for Anti-TRIM24 Antibody Picoband® (monoclonal, 4G6C2) Fluoro488 Conjugated is M03258-2-Fluoro488.

Product Specifications

Background

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene. The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Synonyms

Peptidyl-prolyl cis-trans isomerase B; PPIase B; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP; PPIB; CYPB

Gene Name

TRIM24

Gene ID

8805

UniProt

O15164

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TRIM24 recombinant protein (Position: A706-D964) .

Clonality

Monoclonal

Clone

Clone: 4G6C2

Tissue Specificity

Expressed predominantly in placenta.

Applications

Flow Cytometry

Field of Research

ER Proteins, Immunology, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.

References & Citations

1. Beckstead, R., Ortiz, J. A., Sanchez, C., Prokopenko, S. N., Chambon, P., Losson, R., Bellen, H. J. Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit beta-FTZ-F1-dependent transcription. Molec. Cell 7: 753-765, 2001. 2. Ignat, M., Teletin, M., Tisserand, J., Khetchoumian, K., Dennefeld, C., Chambon, P., Losson, R., Mark, M. Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1-alpha. Proc. Nat. Acad. Sci. 105: 2598-2603, 2008. 3. Khetchoumian, K., Teletin, M., Tisserand, J., Mark, M., Herquel, B., Ignat, M., Zucman-Rossi, J., Cammas, F., Lerouge, T., Thibault, C., Metzger, D., Chambon, P., Losson, R. Loss of Trim24 (Tif1-alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nature Genet. 39: 1500-1506, 2007.