Anti-Erlin-2/ERLIN2 Antibody Picoband® (monoclonal, 3H9A2) Fluoro488 Conjugated
Product Specifications
Background
Erlin-2 is a protein that in humans is encoded by the ERLIN2 gene. This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18) . Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms
T-complex protein 1 subunit gamma; TCP-1-gamma; CCT-gamma; hTRiC5; CCT3; CCTG; TRIC5
Gene Name
ERLIN2
Gene ID
11160
UniProt
O94905
Host
Mouse
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Erlin-2/ERLIN2 recombinant protein (Position: D87-N339) .
Clonality
Monoclonal
Clone
Clone: 3H9A2
Tissue Specificity
Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
Applications
Flow Cytometry
Field of Research
Chaperones, Protein Trafficking, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
References & Citations
1. Al-Saif, A., Bohlega, S., Al-Mohanna, F. Loss of ERLIN2 function leads to juvenile primary lateral sclerosis. Ann. Neurol. 72: 510-516, 2012. 2. Alazami, A. M., Adly, N., Al Dhalaan, H., Alkuraya, F. S. A nullimorphic ERLIN2 mutation defines a complicated hereditary spastic paraplegia locus (SPG18) . Neurogenetics 12: 333-336, 2011. 3. Browman, D. T., Resek, M. E., Zajchowski, L. D., Robbins, S. M. Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER. J. Cell Sci. 119: 3149-3160, 2006.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Chaperonin containing TCP1 subunit 3
Subcellular Location
Cytoplasm.
Isotype
Mouse IgG2b
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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