Anti-TRPV3 Antibody Picoband® Fluoro550 Conjugated

Transient receptor potential cation channel, subfamily V, member 3, also known as TRPV3, is a human gene encoding the protein of the same name. This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene.

A synthetic peptide corresponding to a sequence at the N-terminus of human TRPV3, which shares 77.8% amino acid (aa) sequence identity with mouse TRPV3.

Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion. Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles.

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression.

1. Asakawa, M., Yoshioka, T., Matsutani, T., Hikita, I., Suzuki, M., Oshima, I., Tsukahara, K., Arimura, A., Horikawa, T., Hirasawa, T., Sakata, T. Association of a mutation in TRPV3 with defective hair growth in rodents. J. Invest. Derm. 126: 2664-2672, 2006. 2. Cheng, X., Jin, J., Hu, L., Shen, D., Dong, X., Samie, M. A., Knoff, J., Eisinger, B., Liu, M., Huang, S. M., Caterina, M. J., Dempsey, P., Michael, L. E., Dlugosz, A. A., Andrews, N. C., Clapham, D. E., Xu, H. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell 141: 331-343, 2010. 3. Duchatelet, S., Pruvost, S., de Veer, S., Fraitag, S., Nitschke, P., Bole-Feysot, C., Bodemer, C., Hovnanian, A. A new TRPV3 missense mutation in a patient with Olmsted syndrome and erythromelalgia. JAMA Derm. 150: 303-306, 2014.