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Anti-KCND1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as Kv4.1, is a human gene. It is mapped to Xp11.23. KCND1 encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. The diverse functions of Voltage-gated potassium (Kv) channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. In addition to that, KCND1 is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.

Synonyms

Protein eva-1 homolog A; Protein FAM176A; Transmembrane protein 166; EVA1A; FAM176A; TMEM166; SP24

Gene Name

KCND1

Gene ID

3750

UniProt

Q9NSA2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human KCND1 recombinant protein (Position: E70-D593) .

Clonality

Polyclonal

Tissue Specificity

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.

Applications

Flow Cytometry

Field of Research

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes

Purification

Immunogen affinity purified.

Form

Liquid

Function

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

References & Citations

1. Entrez Gene: KCND1 potassium voltage-gated channel, Shal-related subfamily, member 1 2. Isbrandt, D., Leicher, T., Waldschutz, R., Zhu, X., Luhmann, U., Michel, U., Sauter, K., Pongs, O. Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I (to) and I (sa) . Genomics 64: 144-154, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Eva-1 homolog A, regulator of programmed cell death

Subcellular Location

Endoplasmic reticulum membrane, Single-pass membrane protein, Lysosome membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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