Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-CD103/Itgae Antibody Fluoro488 Conjugated

Product Specifications

Background

ITGAE (INTEGRIN, ALPHA-E), also known as CD103, is an integrin protein that in human is encoded by the ITGAE gene. The ITGAE gene is mapped to chromosome 17p13 by inclusion within a BAC contig. ITGAE is expressed widely on intraepithelial lymphocyte (IEL) T cells (both alphabeta T cells and gammadelta T cells) and on some peripheral regulatory T cells (Tregs) which is important for decreasing the immune response and appears to play a crucial role in the prevention of autoimmune diseases. ITGAE shares overall homology with other alpha integrins but has a unique 55-amino acid extra region located just N-terminal to the I domain that contains 18 consecutive charged residues and a proteolytic cleavage site.

Synonyms

Ribosome-binding protein 1; 180 kDa ribosome receptor homolog; RRp; ES/130-related protein; Ribosome receptor protein; RRBP1; KIAA1398

Gene Name

Itgae

Gene ID

16407

UniProt

Q60677

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived mouse CD103/Itgae recombinant protein (Position: F20-E1061) .

Clonality

Polyclonal

Tissue Specificity

Expressed in kidney.

Applications

Flow Cytometry

Field of Research

Cancer, DNA/RNA, Epigenetics and Nuclear Signaling, Ribosome, Translation, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

References & Citations

1. Cerf-Bensussan, N., Jarry, A., Brousse, N., Lisowska-Grospierre, B., Guy-Grand, D., Griscelli, C. A monoclonal antibody (HML-1) defining a novel membrane molecular present on human intestinal lymphocytes. Europ. J. Immun. 17: 1279-1285, 1987. 2. Parker, C. M., Cepek, K. L, Russell, G. J., Shaw, S. K., Posnett, D. N., Schwarting, R., Brenner, M. B. A family of beta-7 integrins on human mucosal lymphocytes. Proc. Nat. Acad. Sci. 89: 1924-1928, 1992. 3. Kilshaw PJ, Higgins JM (2002) . Alpha E: no more rejection?.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Ribosome binding protein 1

Subcellular Location

Endoplasmic reticulum membrane, Single-pass type III membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

FBXO30 Human siRNA Oligo Duplex (Locus ID 84085)
SR313343 1 Kit

FBXO30 Human siRNA Oligo Duplex (Locus ID 84085)

Ask
View Details
Human PNPLA3 (Patatin Like Phospholipase Domain Containing Protein 3) ELISA Kit
EH25863 96 Tests

Human PNPLA3 (Patatin Like Phospholipase Domain Containing Protein 3) ELISA Kit

Ask
View Details
Rabbit Polyclonal Niemann-Pick type C1 Like-1 Antibody [DyLight 488]
NB400-127G 0.1 mL

Rabbit Polyclonal Niemann-Pick type C1 Like-1 Antibody [DyLight 488]

Ask
View Details
4BP-TQS 10mg
A22084-10 10 mg

4BP-TQS 10mg

Ask
View Details