What sizes are available for Anti-IL34 Antibody Picoband® Fluoro488 Conjugated?

Anti-IL34 Antibody Picoband® Fluoro488 Conjugated is available in the following size(s): 100 µg/Vial.

Is Anti-IL34 Antibody Picoband® Fluoro488 Conjugated in stock?

Anti-IL34 Antibody Picoband® Fluoro488 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

Anti-IL34 Antibody Picoband® Fluoro488 Conjugated

Q: What is the catalog number for Anti-IL34 Antibody Picoband® Fluoro488 Conjugated?

The catalog number for Anti-IL34 Antibody Picoband® Fluoro488 Conjugated is A06903-3-Fluoro488.

Selected Variant

A06903-3-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Interleukin 34 (IL-34) is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening of secreted proteins; chimpanzee, murine, rat and chicken interleukin 34 orthologs have also been found. The protein is composed of 241 amino acids, 39 kilodaltons in mass, and forms homodimers. IL-34 increases growth or survival of immune cells known as monocytes; it elicits its activity by binding the Colony stimulating factor 1 receptor. This gene is mapped to 16q22.1.

Synonyms

Interleukin-34; IL-34; IL34; C16orf77

Gene Name

IL34

Gene ID

146433

UniProt

Q6ZMJ4

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human IL34 recombinant protein (Position: N21-R48) .

Clonality

Polyclonal

Tissue Specificity

Detected in the sinusoidal epithelium in the red pulp of spleen. Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.

Applications

Flow Cytometry

Field of Research

Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

References & Citations

1. Gross, M. B. Personal Communication. Baltimore, Md. 5/30/2014. 2. Lin, H., Lee, E., Hestir, K., Leo, C., Huang, M., Bosch, E., Halenbeck, R., Wu, G., Zhou, A., Behrens, D., Hollenbaugh, D., Linnemann, T., Qin, M., Wong, J., Chu, K., Doberstein, S. K., Williams, L. T. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science 320: 807-811, 2008.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

87148 MW

Applications Notes

Gene Name Synonym

Interleukin 34

Subcellular Location

Secreted.

Protein Name

ADAM metallopeptidase domain 28

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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