Anti-TOX Antibody Picoband®

Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene. The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels inly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804) . Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons.

1. Alfei, F., Kanev, K., Hofmann, M., Wu, M., Ghoneim, H. E., Roelli, P., Utzschneider, D. T., von Hoesslin, M., Cullen, J. G., Fan, Y., Eisenberg, V., Wohlleber, D., Steiger, K., Merkler, D., Delorenzi, M., Knolle, P. A., Cohen, C. J., Thimme, R., Youngblood, B., Zehn, D. TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection. Nature 571: 265-269, 2019. 2. Grant, A. V., El Baghdadi, J., Sabri, A., El Azbaoui, S., Alaoui-Tahiri, K., Rhorfi, I. A., Gharbaoui, Y., Abid, A., Benkirane, M., Raharimanga, V., Richard, V., Orlova, M., and 11 others. Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region. Am. J. Hum. Genet. 92: 407-414, 2013. 3. Gross, M. B. Personal Communication. Baltimore, Md. 5/7/2013.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.