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Anti-Neurotensin Receptor 1/NTSR1 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

A04610-4-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene. Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion.

Synonyms

Thioredoxin, mitochondrial; MTRX; Mt-Trx; Thioredoxin-2; TXN2; TRX2

Gene Name

NTSR1

Gene ID

4923

UniProt

P30989

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Neurotensin Receptor 1/NTSR1 recombinant protein (Position: A15-D400) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed in adult (at protein level) and fetal tissues.

Applications

Flow Cytometry

Field of Research

Hematopoietic Progenitors, Immunology, Innate Immunity, Stem Cells, Surface Molecules

Purification

Immunogen affinity purified.

Form

Liquid

Function

Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.

References & Citations

1. Huang, W., Masureel, M., Qu, Q., Janetzko, J., Inoue, A., Kato, H. E., Robertson, M. J., Nguyen, K. C., Glenn, J. S., Skiniotis, G., Kobilka, B. K. Structure of the neurotensin receptor 1 in complex with beta-arrestin 1. Nature 579: 303-308, 2020. 2. Kato, H. E., Zhang, Y., Hu, H., Suomivuori, C.-M., Kadji, F. M. N., Aoki, J., Krishna Kumar, K., Fonseca, R., Hilger, D., Huang, W., Latorraca, N. R., Inoue, A., Dror, R. O., Kobilka, B. K., Skiniotis, G. Conformational transitions of a neurotensin receptor 1-G (i1) complex. Nature 572: 80-85, 2019. 3. Laurent, P., Clerc, P., Mattei, M.-G., Forgez, P., Dumont, X., Ferrara, P., Caput, D., Rostene, W. Chromosomal localization of mouse and human neurotensin receptor genes. Mammalian Genome 5: 303-306, 1994.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Thioredoxin 2

Subcellular Location

Mitochondrion.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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