Anti-MUC5B Antibody Fluoro647 Conjugated

Mucin 5B (MUC5B/Muc5b) is a protein that in humans is encoded by the MUC5B gene and by Muc5b gene in mouse. This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.

May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

1. Desseyn, J.-L., Aubert, J.-P., van Seuningen, I., Porchet, N., Laine, A. Genomic organization of the 3-prime region of the human mucin gene MUC5B. J. Biol. Chem. 272: 16873-16883, 1997. 2. Desseyn, J.-L., Buisine, M. P., Porchet, N., Aubert, J.-P., Laine, A. Genomic organization of the human mucin gene MUC5B, cDNA and genomic sequences upstream of the large central exon. J. Biol. Chem. 273: 30157-30164, 1998. 3. Desseyn, J.-L., Guyonnet-Duperat, V., Porchet, N., Aubert, J.-P., Laine, A. Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat: structural evidence for a 11p15.5 gene family. J. Biol. Chem. 272: 3168-3178, 1997.