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Anti-Choline Acetyltransferase/CHAT Antibody Picoband®

Boster Bio Anti-Choline Acetyltransferase/CHAT Antibody Picoband® catalog # A01192-6. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Choline acetyltransferase (commonly abbreviated asChAT, but sometimesCAT) is atransferaseenzymeresponsible for the synthesis of theneurotransmitteracetylcholine. In humans, the choline acetyltransferase enzyme is encoded by theCHATgene. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.

Synonyms

Choline O-acetyltransferase (EC:2.3.1.6) ; CHOACTase; ChAT; Choline acetylase; Chat

Gene Name

CHAT

Gene ID

1103

UniProt

P28329

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Choline Acetyltransferase/CHAT recombinant protein (Position: L131-S704) .

Clonality

Polyclonal

Applications

WB, Flow Cytometry, ELISA

Field of Research

Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.

References & Citations

1. Cohen-Haguenauer, O., Brice, A., Berrard, S., Van Cong, N., Mallet, J., Frezal, J. Localization of the choline acetyltransferase (CHAT) gene to human chromosome 10. Genomics 6: 374-378, 1990. 2. Harold, D., Peirce, T., Moskvina, V., Myers, A., Jones, S., Hollingworth, P., Moore, P., Lovestone, S., Powell, J., Foy, C., Archer, N., Walter, S., and 11 others. Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. Hum. Genet. 113: 258-267, 2003. 3. Kraner, S, Laufenberg, I., Strassburg, H. M., Sieb, J. P., Steinlein, O. K. Congenital myasthenic syndrome with episodic apnea in patients homozygous for a CHAT missense mutation. Arch. Neurol. 60: 761-763, 2003.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

82536 MW

Observed Molecular Weight

71 kDa

Applications Notes

6

Gene Name Synonym

Choline O-acetyltransferase

Subcellular Location

Cytoplasm. Neuron projection.

Protein Name

Choline O-acetyltransferase

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

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