Anti-ATE1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants.
Synonyms
BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5; BAG5; KIAA0873
Gene Name
ATE1
Gene ID
11101
UniProt
O95260
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human ATE1 recombinant protein (Position: R56-A459) .
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues examined with lower levels in brain and testis.
Applications
Flow Cytometry
Field of Research
Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity) . May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. .
References & Citations
1. Hu, R.-G., Sheng, J., Qi, X., Xu, Z., Takahashi, T. T., Varshavsky, A. The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators. Nature 437: 981-986, 2005. 2. Kaji, H., Novelli, G. D., Kaji, A. A soluble amino acid-incorporating system from rat liver. Biochim. Biophys. Acta 76: 474-477, 1963. 3. Karakozova, M., Kozak, M., Wong, C. C. L., Bailey, A. O., Yates, J. R, III, Mogilner, A., Zebroski, H., Kashina, A. Arginylation of beta-actin regulates actin cytoskeleton and cell motility. Science 313: 192-196, 2006.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
51200 MW
Applications Notes
6
Gene Name Synonym
BAG family molecular chaperone regulator 5
Subcellular Location
Perinuclear region.
Protein Name
BAG family molecular chaperone regulator 5
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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