Anti-MS2/ADAM8 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.
Synonyms
Calretinin; CR; 29 kDa calbindin; CALB2; CAB29
Gene Name
ADAM8
Gene ID
101
UniProt
P78325
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MS2/ADAM8 recombinant protein (Position: R41-L290) .
Clonality
Polyclonal
Tissue Specificity
Brain.
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunoglobulins, Immunology, Lymphoid, Receptors, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Calretinin is a calcium-binding protein which is abundant in auditory neurons.
References & Citations
1. Hernandez, I., Moreno, J. L., Zandueta, C., Montuenga, L., Lecanda, F. Novel alternatively spliced ADAM8 isoforms contribute to the aggressive bone metastatic phenotype of lung cancer. Oncogene 29: 3758-3769, 2010. 2. Higuchi, Y., Kataoka, M., Yamamoto, S. MS2 (ADAM 8), a myelomonocytic cell surface antigen: expression, chromosomal localization and production of truncated ADAM 8 transgenic mice. (Abstract) Tissue Antigens 48: 423 only, 1996. 3. Kelly, K., Hutchinson, G., Nebenius-Oosthuizen, D., Smith, A. J. H., Bartsch, J. W., Horiuchi, K., Rittger, A., Manova, K., Docherty, A. J. P., Blobel, C. P. Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice. Dev. Dyn. 232: 221-231, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Calbindin 2
Subcellular Location
Cuticular plate. Cytosol. Nucleus. Synaptic membrane. Dendrite. Gap junction. Neuron projection. Parallel fiber to Purkinje cell synapse. Presynapse. Stereocilium. Synapse.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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