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Anti-Desmoplakin/DSP Antibody Picoband®

Boster Bio Anti-Desmoplakin/DSP Antibody Picoband® catalog # A00616-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Desmoplakin is a protein in humans that is encoded by the DSP gene. This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants.

Synonyms

Desmoplakin; DP; 250/210 kDa paraneoplastic pemphigus antigen; DSP

Gene Name

DSP

Gene ID

1832

UniProt

P15924

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Desmoplakin/DSP recombinant protein (Position: N69-H2195) .

Clonality

Polyclonal

Tissue Specificity

Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin.

Applications

ELISA, Flow Cytometry, WB

Field of Research

Calcium Binding Proteins, Calcium Signaling, Cell Biology, Cell Cycle, Cell Differentiation, Cytoskeleton/ECM, Developmental Biology, ECM Proteins, Extracellular Matrix, Organogenesis, Signal Transduction, Signaling Pathway, Skeletal Development, Structures

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

References & Citations

1. Choi HJ, Weis WI (2011) . Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain. J. Mol. Biol. 409 (5) : 800–12. 2. Green KJ, Parry DA, Steinert PM, Virata ML, Wagner RM, Angst BD, Nilles LA (Feb 1990) . Structure of the human desmoplakins. Implications for function in the desmosomal plaque. The Journal of Biological Chemistry. 265 (5) : 2603–12. 3. Jonkman MF, Pasmooij AM, Pasmans SG, van den Berg MP, Ter Horst HJ, Timmer A, Pas HH (Oct 2005) . Loss of desmoplakin tail causes lethal acantholytic epidermolysis bullosa. American Journal of Human Genetics. 77 (4) : 653–60.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

57371 MW

Observed Molecular Weight

250 kDa

Applications Notes

6

Gene Name Synonym

Desmoplakin

Subcellular Location

Cell junction, desmosome.

Protein Name

Steroid 17-alpha-hydroxylase/17,20 lyase

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

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