Anti-Cdk2 Antibody Picoband® (monoclonal, 6D5B5) Fluoro488 Conjugated

Product Specifications

Background

CDK2, Cyclin-Dependent Kinase2, is also known as P33. The CDK2 protein was highly homologous to p34 (CDC2) kinase and more significantly homologous to Xenopus Eg1 kinase, suggesting that CDK2 is the human homolog of Eg1. The CDK2 gene is mapped to 12q13, the same region to which the CDK4 gene maps. Human cyclin A binds independently to 2 kinases, p34 (cdc2) or p33. In adenovirus-transformed cells, the viral E1A oncoprotein seems to associate with p33/cyclin A but not with p34 (cdc2) /cyclin A. The gene for p33 shares 65% sequence identity with p34 (cdc2) . P33 (cdk2) plays a unique role in cell cycle regulation of vertebrate cells.

Synonyms

Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter; SLC2A1; GLUT1

Gene Name

CDK2

Gene ID

1017

UniProt

P24941

Host

Mouse

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Cdk2 recombinant protein (Position: E81-L298) . Human Cdk2 shares 98.6% amino acid (aa) sequence identity with rat Cdk2.

Clonality

Monoclonal

Clone

Clone: 6D5B5

Tissue Specificity

Detected in erythrocytes (at protein level) . Expressed at variable levels in many human tissues.

Applications

Flow Cytometry

Field of Research

Channels, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.

References & Citations

1. Demetrick, D. J., Zhang, H., Beach, D. H.Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes.Cytogenet. Cell Genet. 66: 72-74, 1994. 2. Tsai, L.-H., Harlow, E., Meyerson, M.Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated P33 kinase.Nature 353: 174-177, 1991.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

46659 MW

Applications Notes

Gene Name Synonym

Solute carrier family 2 (facilitated glucose transporter), member 1

Subcellular Location

Cell membrane. Multi-pass membrane protein. Melanosome.

Protein Name

Isocitrate dehydrogenase [NADP] cytoplasmic

Isotype

Mouse IgG2b

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-Cdk2 Antibody Picoband® (monoclonal, 6D5B5) Fluoro488 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Clone

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Applications Notes

Gene Name Synonym

Subcellular Location

Protein Name

Isotype

Contents

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