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Anti-Sorbitol Dehydrogenase/SORD Antibody Picoband® (monoclonal, 12B10G2) Fluoro647 Conjugated

Selected Variant

M07851-1-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Sorbitol dehydrogenase is an enzyme that in humans is encoded by the SORD gene. Sorbitol dehydrogenase (SORD) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase, makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications. The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD (+) cofactor.

Synonyms

T-complex protein 1 subunit gamma; TCP-1-gamma; CCT-gamma; hTRiC5; CCT3; CCTG; TRIC5

Gene Name

SORD

Gene ID

6652

UniProt

Q00796

Host

Mouse

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Sorbitol Dehydrogenase/SORD recombinant protein (Position: N8-P357) .

Clonality

Monoclonal

Clone

Clone: 12B10G2

Tissue Specificity

Ubiquitously expressed with highest levels in spleen, thymus and immature brain.

Applications

Flow Cytometry

Field of Research

Chaperones, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

References & Citations

1. Carr, I. M., Markham, A. F., Coletta, P. L. Identification and characterisation of a sequence related to human sorbitol dehydrogenase. Europ. J. Biochem. 245: 760-767, 1997. 2. Carr, I. M., Markham, A. F. Molecular genetic analysis of the human sorbitol dehydrogenase gene. Mammalian Genome 6: 645-652, 1995. 3. Carr, I. M., Whitehouse, A., Coletta, P. L., Markham, A. F. Structural and evolutionary characterization of the human sorbitol dehydrogenase gene duplication. Mammalian Genome 9: 1042-1048, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Chaperonin containing TCP1 subunit 3

Subcellular Location

Cytoplasm.

Isotype

Mouse IgG1

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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