Anti-YY1 Antibody Picoband® (monoclonal, 2C10F9) Fluoro488 Conjugated
Product Specifications
Background
YY1 (Yin Yang 1) is a transcriptional repressor protein in humans that is encoded by the YY1 gene. YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
Synonyms
Dihydrofolate reductase; DHFR
Gene Name
YY1
Gene ID
7528
UniProt
P25490
Host
Mouse
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human YY1, identical to the related mouse sequence.
Clonality
Monoclonal
Clone
Clone: 2C10F9
Tissue Specificity
Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain.
Applications
Flow Cytometry
Field of Research
Amino Acid Metabolism, Amino Acids, Cancer, Cell Biology, Metabolic Signaling Pathways, Metabolism, Nucleotide Metabolism, Pathways and Processes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.
References & Citations
1. Shi Y, Seto E, Chang LS, Shenk T (Oct 1991) . Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67 (2) : 377–88. 2. Thiaville MM, Kim J (2011) . Oncogenic potential of yin yang 1 mediated through control of imprinted genes. Critical Reviews in Oncogenesis 16 (3-4) : 199–209. 3. Zhu W, Lossie AC, Camper SA, Gumucio DL (Apr 1994) . Chromosomal localization of the transcription factor YY1 in the mouse and human. Mammalian Genome 5 (4) : 234–6.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Dihydrofolate reductase
Subcellular Location
Mitochondrion. Cytoplasm
Protein Name
Zeta chain of T cell receptor associated protein kinase 70
Isotype
Mouse IgG2a
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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