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Anti-WAPL/FOE Antibody Picoband® Fluoro488 Conjugated

Selected Variant

A03684-2-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

WAPL (wings apart-like), also known as WAPAL or FOE, is a 1,190 amino acid protein that contains one WAPL domain and may play an important role in cell growth. It is expressed in an isoform dependent manner in heart, skeletal muscle (isoform 2) and uterine cervix tumor tissue (isoform 1) . WAPL is involved in sister-chromatid adhesion and promotes release of cohesin from chromosomes by ly interacting with its regulatory subunits. WAPL is a new regulator of the development and metastasis of cancerous tissue.

Synonyms

P-selectin glycoprotein ligand; Selplg; Psgl1

Gene Name

WAPL

Gene ID

23063

UniProt

Q7Z5K2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human WAPL/FOE recombinant protein (Position: Q916-C1190) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in blood, bone marrow, brain, adipose tissue, spleen, and thymus. Also expressed in heart, kidney, liver, muscle, ovary, and stomach.

Applications

Flow Cytometry

Field of Research

Cardiovascular, Cell Biology, Platelets, Protease Inhibitors, Proteolysis/Ubiquitin, Proteolytic Enzymes

Purification

Immunogen affinity purified.

Form

Liquid

Function

A SLe (x) -type proteoglycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.

References & Citations

1. Busslinger, G. A., Stocsits, R. R., van der Lelij, P., Axelsson, E., Tedeschi, A., Galjart, N., Peters, J.-M. Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl. Nature 544: 503-507, 2017. 2. Hill, L., Ebert, A., Jaritz, M., Wutz, G., Nagasaka, K., Tagoh, H., Kostanova-Poliakova, D., Schindler, K., Sun, Q., Bonelt, P., Fischer, M., Peters, J.-M., Busslinger, M. Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion. Nature 584: 142-147, 2020. 3. Kueng, S., Hegemann, B., Peters, B. H., Lipp, J. J., Schleiffer, A., Mechtler, K., Peters, J.-M. Wapl controls the dynamic association of cohesin with chromatin. Cell 127: 955-967, 2006.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

28461 MW

Applications Notes

6

Gene Name Synonym

Selectin P ligand

Subcellular Location

Integral component of membrane.

Protein Name

Breast cancer metastasis-suppressor 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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