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Anti-Dopamine Transporter/SLC6A3 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.

Synonyms

Nitric oxide synthase, inducible;1.14.13.39; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; N

Gene Name

SLC6A3

Gene ID

6531

UniProt

Q01959

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Dopamine Transporter/SLC6A3 recombinant protein (Position: M1-V620) .

Clonality

Polyclonal

Tissue Specificity

Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.

Applications

Flow Cytometry

Field of Research

Cancer, Cancer Metabolism, Metabolism, Metabolism Processes, Neuroscience, Neurotransmission, Pathways and Processes, Response To Hypoxia

Purification

Immunogen affinity purified.

Form

Liquid

Function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. As component of the iNOS- S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys- 247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. .

References & Citations

1. Brookes, K.-J., Mill, J., Guindalini, C., Curran, S., Xu, X., Knight, J., Chen, C.-K., Huang, Y.-S., Sethna, V., Taylor, E., Chen, W., Breen, G., Asherson, P. A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch. Gen. Psychiat. 63: 74-81, 2006. 2. Byerley, W., Hoff, M., Holik, J., Caron, M. G., Giros, B. VNTR polymorphism for the human dopamine transporter gene (DAT1) . Hum. Molec. Genet. 2: 335, 1993. 3. Cheuk, D. K. L., Li, S. Y. H., Wong, V. No association between VNTR polymorphisms of dopamine transporter gene and attention deficit hyperactivity disorder in Chinese children. Am. J. Med. Genet. 141B: 123-125, 2006.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

131117 MW

Applications Notes

6

Gene Name Synonym

Nitric oxide synthase, inducible

Subcellular Location

Nucleus.

Protein Name

Nitric oxide synthase, inducible

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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