Anti-P2Y6/P2RY6 Antibody Picoband®

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene. The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

A synthetic peptide corresponding to a sequence at the C-terminusof human P2Y6/P2RY6, which shares 94.4% amino acid (aa) sequence identity with rat P2RY6.

1. Chang, K., Hanaoka, K., Kumada, M., Takuwa, Y. Molecular cloning and functional analysis of a novel P2 nucleotide receptor. J. Biol. Chem. 270: 26152-26158, 1995. 2. Communi, D., Parmentier, M., Boeynaems, J.-M. Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem. Biophys. Res. Commun. 222: 303-308, 1996. 3. Giannattasio, G., Ohta, S., Boyce, J. R., Xing, W., Balestrieri, B., Boyce, J. A. The purinergic G protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation. J. Immun. 187: 1486-1495, 2011.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.