Anti-GAS2 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene. The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants.

Synonyms

Gap junction gamma-1 protein; Connexin-45; Cx45; Gap junction alpha-7 protein; GJC1; GJA7

Gene Name

GAS2

Gene ID

2620

UniProt

O43903

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human GAS2, identical to the related mouse sequences.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed.

Applications

Flow Cytometry

Field of Research

Cell Adhesion, Cytoskeleton/ECM, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

References & Citations

1. Brancolini, C., Bottega, S., Schneider, C. Gas2, a growth arrest-specific protein, is a component of the microfilament network system. J. Cell Biol. 117: 1251-1261, 1992. 2. Collavin, L., Buzzai, M., Saccone, S., Bernard, L., Federico, C., DellaValle, G., Brancolini, C., Schneider, C. cDNA characterization and chromosome mapping of the human GAS2 gene. Genomics 48: 265-269, 1998. 3. Colombo, M. P., Martinotti, A., Howard, T. A., Schneider, C., D'Eustachio, P., Seldin, M. F. Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16. Mammalian Genome 2: 130-134, 1992.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

45470 MW

Applications Notes

Gene Name Synonym

Gap junction gamma-1 protein

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Protein Name