Anti-p19 INK4d/CDKN2D Antibody Picoband®

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene. The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590) . Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590) . Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity) . Modulates prostaglandin E2 secretion (PubMed:21242590) .

1. Chen, P., Zindy, F., Abdala, C., Liu, F., Li, X., Roussel, M. F., Segil, N. Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d. Nature Cell Biol. 5: 422-426, 2003. 2. Hirai, H., Roussel, M. F., Kato, J.-Y., Ashmun, R. A., Sherr, C. J. Novel INK4 proteins, p19 and p18, are specific inhibitors of cyclin D-dependent kinases CDK4 and CDK6. Molec. Cell. Biol. 15: 2672-2681, 1995. 3. Matsuzaki, Y., Miyazawa, K., Yokota, T., Hitomi, T., Yamagishi, H., Sakai, T. Molecular cloning and characterization of the human p19 (INK4d) gene promoter. FEBS Lett. 517: 272-276, 2002.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.