Anti-Azurocidin/AZU1 Antibody Picoband® Fluoro488 Conjugated

Azurocidin also known as cationic antimicrobial protein CAP37 or heparin-binding protein (HBP) is a protein that in humans is encoded by the AZU1 gene. Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland) .

Cancer, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Immunology, Invasion/Microenvironment, Secreted Molecules, Signal Transduction, Tumor Biomarkers

May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.

1. Morgan, J. G. , Sukiennicki, T. , Pereira, H. A. , Spitznagel, J. K. , & Larrick, J. W. . (1991) . Cloning of the cdna for the serine protease homolog cap37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. The Journal of Immunology, 147 (9), 3210-3214. 2. M, Zimmer, R, L, Medcalf, & T, et al. (1992) . Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. Proceedings of the National Academy of Sciences of the United States of America. 3. Gautam, N. , Olofsson, A. M. , Herwald, H. , Iversen, L. F. , & Lindbom, L. . (2001) . Heparin-binding protein (hbp/cap37) : a missing link in neutrophil-evoked alteration of vascular permeability. Nature Medicine, 7 (10), 1123.