Anti-SDF2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
The protein encoded by this gene is believed to be a secretory protein. It has regions of similarity to hydrophilic segments of yeast mannosyltransferases. Its expression is ubiquitous and the gene appears to be relatively conserved among mammals. Alternate splicing results in both coding and non-coding variants. A pseudogene of this gene is located on chromosome 15.
Synonyms
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8; CPAMD8; KIAA1283
Gene Name
SDF2
Gene ID
6388
UniProt
Q99470
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human SDF2 recombinant protein (Position: K75-L211) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. Expressed in the lens, cornea and retina. Strongly expressed in the distal tips of the retinal neuroepithelium that form the iris and ciliary body.
Applications
Flow Cytometry
Field of Research
Complement, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
References & Citations
1. Hamada, T., Tashiro, K., Tada, H., Inazawa, J., Shirozu, M., Shibahara, K., Nakamura, T., Martina, N., Nakano, T., Honjo, T. Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method. Gene 176: 211-214, 1996.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
C3 and PZP like, alpha-2-macroglobulin domain containing 8
Subcellular Location
Secreted. Cell membrane. Peripheral membrane protein. Extracellular side.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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