Anti-Calponin 3/CNN3 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Calponin 3. acidic is a protein that in humans is encoded by the CNN3 gene. This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction.
Synonyms
Neuropeptides B/W receptor type 1; G-protein coupled receptor 7; NPBWR1; GPR7
Gene Name
CNN3
Gene ID
1266
UniProt
Q15417
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Calponin 3/CNN3, identical to the related mouse and rat sequences.
Clonality
Polyclonal
Tissue Specificity
Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.
Applications
Flow Cytometry
Field of Research
Immune System Diseases, Immunology, Protein Trafficking, Signal Transduction, Signaling Pathway
Purification
Immunogen affinity purified.
Form
Liquid
Function
Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.
References & Citations
1. Maguchi, M., Nishida, W., Kohara, K., Kuwano, A., Kondo, I., Hiwada, K. Molecular cloning and gene mapping of human basic and acidic calponins. Biochem. Biophys. Res. Commun. 217: 238-244, 1995.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Neuropeptides B and W receptor 1
Subcellular Location
Cell membrane. Multi-pass membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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