Anti-Calponin 2/CNN2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Calponin 2 is a protein that in humans is encoded by the CNN2 gene. The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms
Annexin A8 ; Annexin VIII ; Annexin-8 ; Vascular anticoagulant-beta ; VAC-beta ; ANXA8 ; ANX8
Gene Name
CNN2
Gene ID
1265
UniProt
Q99439
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Calponin 2/CNN2, which shares 75% amino acid (aa) sequence identity with mouse CNN2.
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed.
Applications
Flow Cytometry
Field of Research
Signal Transduction, Cardiovascular, Cytoskeleton, Cytoskeleton/ECM, Actin Binding Proteins, Actin, etc., Microfilaments, Cell Adhesion
Purification
Immunogen affinity purified.
Form
Liquid
Function
This protein is an anticoagulant protein that acts as an in inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
References & Citations
1. Cheng, J.-F., Boyartchuk, V., Zhu, Y. Isolation and mapping of human chromosome 21 cDNA: progress in constructing a chromosome 21 expression map. Genomics 23: 75-84, 1994. 2. Gross, M. B. Personal Communication. Baltimore, Md. 2/16/2011. 3. Masuda, H., Tanaka, K., Takagi, M., Ohgami, K., Sakamaki, T., Shibata, N., Takahashi, K. Molecular cloning and characterization of human non-smooth muscle calponin. J. Biochem. 120: 415-424, 1996.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
36881 MW
Applications Notes
6
Gene Name Synonym
Annexin A8
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein Name
Annexin A8
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
More Discoveries
Explore Other Products
Browse additional items from our catalog
NBP2-97288JF549 0.1 mL
Rabbit Polyclonal OS9 Antibody [Janelia Fluor 549]
Sign In for Pricing
View Details 
