Anti-CBX2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene. This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Synonyms
Rho-related GTP-binding protein Rho6; Rho family GTPase 1; Rnd1; RND1; RHO6
Gene Name
CBX2
Gene ID
84733
UniProt
Q14781
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human CBX2 recombinant protein (Position: M1-Y532) .
Clonality
Polyclonal
Tissue Specificity
Mostly expressed in brain and liver.
Applications
Flow Cytometry
Field of Research
Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, G Protein Signaling, Microfilaments, Ras Family, Signal Transduction, Signaling Pathway, Small G Proteins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. .
References & Citations
1. Biason-Lauber, A., Konrad, D., Meyer, M., deBeaufort, C., Schoenle, E. J. Ovaries and female phenotype in a girl with 46, XY karyotype and mutations in the CBX2 gene. Am. J. Hum. Genet. 84: 658-663, 2009. 2. Gecz, J., Gaunt, S. J., Passage, E., Burton, R. D., Cudrey, C., Pearce, J. J. H., Fontes, M. Assignment of a polycomb-like chromobox gene (CBX2) to human chromosome 17q25. Genomics 26: 130-133, 1995. 3. Katoh-Fukui, Y., Tsuchiya, R., Shiroishi, T., Nakahara, Y., Hashimoto, N., Noguchi, K., Higashinakagawa, T. Male-to-female sex reversal in M33 mutant mice. Nature 393: 688-692, 1998.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
26056 MW
Applications Notes
6
Gene Name Synonym
Rho-related GTP-binding protein Rho6
Subcellular Location
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytoskeleton .
Protein Name
AP-2 complex subunit mu
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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