Anti-ATG16L1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10) . Several transcript variants encoding different isoforms have been found for this gene.
Synonyms
Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin; Afp
Gene Name
ATG16L1
Gene ID
55054
UniProt
Q676U5
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human ATG16L1 recombinant protein (Position: R66-K359) .
Clonality
Polyclonal
Tissue Specificity
Plasma.
Applications
Flow Cytometry
Field of Research
Cancer, Cardiovascular, Developmental Biology, Organogenesis, Serum Proteins, Tumor Antigens, Tumor Biomarkers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Binds estrogens, fatty acids and metals.
References & Citations
1. Adolph, T. E., Tomczak, M. F., Niederreiter, L., Ko, H.-J., Bock, J., Martinez-Naves, E., Glickman, J. N., Tschurtschenthaler, M., Hartwig, J., Hosomi, S., Flak, M. B., Cusick, J. L., and 14 others. Paneth cells as a site of origin for intestinal inflammation. Nature 503: 272-276, 2013. 2. Bel, S., Pendse, M., Wang, Y., Li, Y., Ruhn, K. A., Hassell, B., Leal, T., Winter, S. E., Xavier, R. J., Hooper, L. V. Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine. Science 357: 1047-1052, 2017. 3. Boada-Romero, E., Serramito-Gomez, I., Sacristan, M. P., Boone, D. L., Xavier, R. J., Pimentel-Muinos, F. X. The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1. Nature Commun. 7: 11821, 2016. Note: Electronic Article.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Alpha-fetoprotein
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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