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Anti-ATG16L1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10) . Several transcript variants encoding different isoforms have been found for this gene.

Synonyms

Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin; Afp

Gene Name

ATG16L1

Gene ID

55054

UniProt

Q676U5

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human ATG16L1 recombinant protein (Position: R66-K359) .

Clonality

Polyclonal

Tissue Specificity

Plasma.

Applications

Flow Cytometry

Field of Research

Cancer, Cardiovascular, Developmental Biology, Organogenesis, Serum Proteins, Tumor Antigens, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Binds estrogens, fatty acids and metals.

References & Citations

1. Adolph, T. E., Tomczak, M. F., Niederreiter, L., Ko, H.-J., Bock, J., Martinez-Naves, E., Glickman, J. N., Tschurtschenthaler, M., Hartwig, J., Hosomi, S., Flak, M. B., Cusick, J. L., and 14 others. Paneth cells as a site of origin for intestinal inflammation. Nature 503: 272-276, 2013. 2. Bel, S., Pendse, M., Wang, Y., Li, Y., Ruhn, K. A., Hassell, B., Leal, T., Winter, S. E., Xavier, R. J., Hooper, L. V. Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine. Science 357: 1047-1052, 2017. 3. Boada-Romero, E., Serramito-Gomez, I., Sacristan, M. P., Boone, D. L., Xavier, R. J., Pimentel-Muinos, F. X. The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1. Nature Commun. 7: 11821, 2016. Note: Electronic Article.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Alpha-fetoprotein

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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