Anti-ATG16L1 Antibody Picoband®

Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10) . Several transcript variants encoding different isoforms have been found for this gene.

1. Adolph, T. E., Tomczak, M. F., Niederreiter, L., Ko, H.-J., Bock, J., Martinez-Naves, E., Glickman, J. N., Tschurtschenthaler, M., Hartwig, J., Hosomi, S., Flak, M. B., Cusick, J. L., and 14 others. Paneth cells as a site of origin for intestinal inflammation. Nature 503: 272-276, 2013. 2. Bel, S., Pendse, M., Wang, Y., Li, Y., Ruhn, K. A., Hassell, B., Leal, T., Winter, S. E., Xavier, R. J., Hooper, L. V. Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine. Science 357: 1047-1052, 2017. 3. Boada-Romero, E., Serramito-Gomez, I., Sacristan, M. P., Boone, D. L., Xavier, R. J., Pimentel-Muinos, F. X. The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1. Nature Commun. 7: 11821, 2016. Note: Electronic Article.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.