Anti-TUBGCP2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene. It is part of the gamma tubulin complex, which required formicrotubule nucleation at the centrosome. Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.
Synonyms
Neutrophil defensin 1; Defensin, alpha 1; HNP-1; HP-1; HP1; HP 1-56; Neutrophil defensin 2; HNP-2; HP-2; HP2; DEFA1; DEF1, DEFA2, MRS; DEFA1B
Gene Name
TUBGCP2
Gene ID
10844
UniProt
Q9BSJ2
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human TUBGCP2 recombinant protein (Position: Q213-R888) .
Clonality
Polyclonal
Tissue Specificity
Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.
Applications
Flow Cytometry
Field of Research
Defensin, Human Protein, Immunology, Innate Immunity, Macrophage/Inflammation, Microbiology, Protein, Secreted Molecules
Purification
Immunogen affinity purified.
Form
Liquid
Function
Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. .
References & Citations
1. Hartz, P. A. Personal Communication. Baltimore, Md. 12/18/2017. 2. Mitani, T., Punetha, J., Akalin, I., Pehlivan, D., Dawidziuk, M., Akdemir, Z. C., Yilmaz, S., Aslan, E., Hunter, J. V., Hijazi, H., Grochowski, C. M., Jhangiani, S. N., and 25 others. Bi-allelic pathogenic variants in TUBGCP2 cause microcephaly and lissencephaly spectrum disorders. Am. J. Hum. Genet. 105: 1005-1015, 2019. 3. Murphy, S. M., Urbani, L., Stearns, T. The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components Spc97p and Spc98p. J. Cell Biol. 141: 663-674, 1998.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
10201 MW
Applications Notes
6
Gene Name Synonym
Neutrophil defensin 1
Subcellular Location
Secreted.
Protein Name
Neutrophil defensin 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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