Anti-Cip4/TRIP10 Antibody Picoband® Fluoro488 Conjugated

Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene. TRIP10 (thyroid hormone receptor interactor 10), also known as CIP4 (Cdc42-interacting protein 4), is a novel adaptor protein which may be invloved in plasma membrane remodeling. CIP4 has been reported to negatively regulate glucose uptake by promoting GLUT4 endocytosis in muscle cells. At least five splice variants for human CIP4 have been identified, including CIP4a (CIP4), CIP4b (FELIC), CIP4c, CIPh (CIP4/2) . Western blot analysis usually demonstrates a major band around 75 kDa and a weaker band about 85 kDa.

Sodium-dependent phosphate transport protein 2B; Sodium-phosphate transport protein 2B; Na (+) -dependent phosphate cotransporter 2B; NaPi3b; Sodium/phosphate cotransporter 2B; Na (+) /Pi cotransporter 2B; NaPi-2b; Solute carrier family 34 member 2; SLC34A2

Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.

May be involved in actively transporting phosphate into cells via Na+ cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

1. Aspenstrom, P. A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton. Curr. Biol. 7: 479-487, 1997. 2. Feng, Y., Hartig, S. M., Bechill, J. E., Blanchard, E. G., Caudell, E., Corey, S. J. The Cdc42-interacting protein-4 (CIP4) gene knock-out mouse reveals delayed and decreased endocytosis. J. Biol. Chem. 285: 4348-4354, 2010. 3. Holbert, S., Dedeoglu, A., Humbert, S., Saudou, F., Ferrante, R. J., Neri, C. Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease. Proc. Nat. Acad. Sci. 100: 2712-2717, 2003.