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Anti-TPI1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Triosephosphate isomerase is an enzyme that in humans is encoded by the TPI1 gene. This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.

Synonyms

Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD252; Tnfsf4; Ox40l; Txgp1l

Gene Name

TPI1

Gene ID

7167

UniProt

P60174

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human TPI1 recombinant protein (Position: M1-Q286) .

Clonality

Polyclonal

Tissue Specificity

Macrophages; peripheral blood leukocytes, lung, spleen and liver.

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, Autoimmune, B Cells, Cell Type Markers, Cytokines, Immune System Diseases, Immunology, Innate Immunity, T Cells, TNF Superfamily

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

References & Citations

1. Arya, R., Lalloz, M. R. A., Bellingham, A. J., Layton, D. M. Evidence for founder effect of the glu104-to-asp substitution and identification of new mutations in triosephosphate isomerase deficiency. Hum. Mutat. 10: 290-294, 1997. 2. Asakawa, J., Iida, S. Origin of human triosephosphate isomerase isozymes: further evidence for the single structural locus hypothesis with Japanese variants. Hum. Genet. 71: 22-26, 1985. 3. Asakawa, J., Satoh, C., Takahashi, N., Fujita, M., Kaneko, J., Goriki, K., Hazama, R., Kageoka, T. Electrophoretic variants of blood proteins in Japanese: III. Triosephosphate isomerase. Hum. Genet. 68: 185-188, 1984.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Tumor necrosis factor (ligand) superfamily, member 4

Subcellular Location

Membrane; Single-pass type II membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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