Anti-AP2 gamma/TFAP2C Antibody Picoband®

Transcription factor AP-2 gamma also known as AP2-gamma is a protein that in humans is encoded by the TFAP2C gene. The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube.

Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) . Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541) .

1. Aldred, M. A., Aftimos, S., Hall, C., Waters, K. S., Thakker, R. V., Trembath, R. C., Brueton, L. Constitutional deletion of chromosome 20q in two patients affected with Albright hereditary osteodystrophy. Am. J. Med. Genet. 113: 167-172, 2002. 2. Bosher, J. M., Williams, T., Hurst, H. C. The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma. Proc. Nat. Acad. Sci. 92: 744-747, 1995. 3. Genevieve, D., Sanlaville, D., Faivre, L., Kottler, M.-L., Jambou, M., Gosset, P., Boustani-Samara, D., Pinto, G., Ozilou, C., Abeguile, G., Munnich, A., Romana, S., Raoul, O., Cormier-Daire, V., Vekemans, M. Paternal deletion of the GNAS imprinted locus (including Gnasxl) in two girls presenting with severe pre- and post-natal growth retardation and intractable feeding difficulties. Europ. J. Hum. Genet. 13: 1033-1039, 2005.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.