Anti-TRF1/TERF1 Antibody Picoband® Fluoro488 Conjugated

Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene. This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.

Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577) . May be involved in the metabolic transition between fasting and refeeding: required to fatty acids to adipose tissue for storage in the fed state (By similarity) . .

1. Broccoli, D., Chong, L., Oelmann, S., Fernald, A. A., Marziliano, N., van Steensel, B., Kipling, D., Le Beau, M. M., de Lange, T. Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains. Hum. Molec. Genet. 6: 69-76, 1997. 2. Chen, Y., Yang, Y., van Overbeek, M., Donigian, J. R., Baciu, P., de Lange, T., Lei, M. A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319: 1092-1096, 2008. 3. Chong, L., van Steensel, B., Broccoli, D., Erdjument-Bromage, H., Hanish, J., Tempst, P., de Lange, T. A human telomeric protein. Science 270: 1663-1667, 1995.