Anti-SRI Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Sorcin is a protein that in humans is encoded by the SRI gene. It is mapped to 7q21.1. This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene.
Synonyms
Sorcin; 22 kDa protein; CP-22; CP22; V19; SRI
Gene Name
SRI
Gene ID
6717
UniProt
P30626
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human SRI recombinant protein (Position: D121-A161) .
Clonality
Polyclonal
Tissue Specificity
Detected in cardiac myocytes.
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, Cell Type Markers, Hematopoietic Progenitors, Host-Virus Interaction, Immunology, Interspecies Interaction, Lymphoid, Microbiology, Myeloid, Stem Cells, T Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
References & Citations
1. Entrez Gene: SRI sorcin. 2. Meyers, M B; Pickel V M; Sheu S S; Sharma V K; Scotto K W; Fishman G I (Nov 1995) . Association of sorcin with the cardiac ryanodine receptor. J. Biol. Chem. (UNITED STATES) 270 (44) : 26411–8. 3. Van der Bliek AM, Baas F, Van der Velde-Koerts T, Biedler JL, Meyers MB, Ozols RF, Hamilton TC, Joenje H, Borst P (Nov 1988) . Genes amplified and overexpressed in human multidrug-resistant cell lines. Cancer Res48 (21) : 5927–32.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Sorcin
Subcellular Location
Cytoplasm. Sarcoplasmic reticulum membrane. Peripheral membrane protein. Cytoplasmic side.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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