Anti-SKAP2 Antibody Picoband® Fluoro488 Conjugated

Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene. The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.

1. Kouroku, Y., Soyama, A., Fujita, E., Urase, K., Tsukahara, T., Momoi, T. RA70 is a src kinase-associated protein expressed ubiquitously. Biochem. Biophys. Res. Commun. 252: 738-742, 1998. 2. Liu, J., Kang, H., Raab, M., da Silva, A. J., Kraeft, S.-K., Rudd, C. E. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. Proc. Nat. Acad. Sci. 95: 8779-8784, 1998. 3. Marie-Cardine, A., Verhagen, A. M., Eckerskorn, C., Schraven, B. SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. FEBS Lett. 435: 55-60, 1998.