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Anti-RYR2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Ryanodine receptor 2 (RYR2) is a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2 gene. This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.

Synonyms

B-lymphocyte antigen CD19; Differentiation antigen CD19; CD19; Cd19

Gene Name

RYR2

Gene ID

6262

UniProt

Q92736

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human RYR2 recombinant protein (Position: Q1293-T1423) .

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

References & Citations

1. Benkusky, N. A., Farrell, E. F., Valdivia, H. H. Ryanodine receptor channelopathies. Biochem. Biophys. Res. Commun. 322: 1280-1285, 2004. 2. Bhuiyan, Z. A., van den Berg, M. P., van Tintelen, J. P., Bink-Boelkens, M. T. E., Wiesfeld, A. C. P., Alders, M., Postma, A. V., van Langen, I., Mannens, M. M. A. M., Wilde, A. A. M. Expanding spectrum of human RYR2-related disease: new electrocardiographic, structural, and genetic features. Circulation 116: 1569-1576, 2007. 3. George, C. H., Higgs, G. V., Lai, F. A. Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes. Circ. Res. 93: 531-540, 2003.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

CD19 antigen

Subcellular Location

Membrane; Single-pass type I membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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