Anti-MSK2/RSK-B/RPS6KA4 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene. This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms
Spermine oxidase; Polyamine oxidase 1; PAO-1; PAOh1; Smox; Smo
Gene Name
RPS6KA4
Gene ID
8986
UniProt
O75676
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MSK2/RSK-B/RPS6KA4 recombinant protein (Position: Q302-S772) .
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Isoform 1 and isoform 2 are expressed at higher level in brain and skeletal muscle. Isoform 7 is found in brain and spleen, isoform 10 is widely expressed but found at lower level in heart, kidney, liver and lung.
Applications
Flow Cytometry
Field of Research
Chemokines, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N1-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
References & Citations
1. Deak, M., Clifton, A. D., Lucocq, J. M., Alessi, D. R. Mitogen- and stress-activated protein kinase-1 (MSK1) is ly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 17: 4426-4441, 1998. 2. Gross, M. B. Personal Communication. Baltimore, Md. 5/14/2014. 3. Pierrat, B., Correia, J. S., Mary, J.-L., Tomas-Zuber, M., Lesslauer, W. RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38-alpha mitogen-activated protein kinase (p38-alpha-MAPK) . J. Biol. Chem. 273: 29661-29671, 1998.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A05545-2-Fluoro488
Calculated Molecular Weight
48608 MW
Applications Notes
6
Gene Name Synonym
Spermine oxidase
Subcellular Location
Cytoplasm. Nucleus. Cytoplasm.
Protein Name
Serine protease HTRA3
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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