Anti-PTGIS/PGIS Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Prostaglandin-I synthase (EC 5.3.99.4) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
Synonyms
RNA-binding protein Musashi homolog 1; Musashi-1; MSI1
Gene Name
PTGIS
Gene ID
5740
UniProt
Q16647
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human PTGIS/PGIS recombinant protein (Position: D119-D470) .
Clonality
Polyclonal
Tissue Specificity
Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.
Applications
Flow Cytometry
Field of Research
Cell Type Marker, Cytoplasmic, Intracellular, Neural Stem Cells, Neurogenesis, Neurology Process, Neuroscience, Nuclear, Signaling Pathways, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U1-3AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
References & Citations
1. Chevalier, D., Cauffiez, C., Bernard, C., Lo-Guidice, J.-M., Allorge, D., Fazio, F., Ferrari, N., Libersa, C., Lhermitte, M., D'Halluin, J.-C., Broly, F. Characterization of new mutations in the coding sequence and 5-prime-untranslated region of the human prostacyclin synthase gene (CYP8A1) . Hum. Genet. 108: 148-155, 2001. 2. Miyata, A., Hara, S., Yokoyama, C., Inoue, H., Ullrich, V., Tanabe, T. Molecular cloning and expression of human prostacyclin synthase. Biochem. Biophys. Res. Commun. 200: 1728-1734, 1994. 3. Nakayama, T., Soma, M., Watanabe, Y., Hasimu, B., Sato, M., Aoi, N., Kosuge, K., Kanmatsuse, K., Kokubun, S., Marrow, J. D., Oates, J. A. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. Biochem. Biophys. Res. Commun. 297: 1135-1139, 2002.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39125 MW
Applications Notes
6
Gene Name Synonym
Musashi RNA binding protein 1
Subcellular Location
Nucleus. Cytoplasm.
Protein Name
RNA-binding protein Musashi homolog 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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