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Anti-PROX1 Antibody Picoband®

Boster Bio Anti-PROX1 Antibody Picoband® catalog # A01985-1. Tested in ELISA, Flow Cytometry, IP, ICC, IF, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Prospero homeobox protein 1, also called PROX1 is a protein that in humans is encoded by the PROX1 gene. This gene is mapped to 1q32.3. The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus.

Synonyms

Neuronal acetylcholine receptor subunit alpha-3; CHRNA3; NACHRA3

Gene Name

PROX1

Gene ID

5629

UniProt

Q92786

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PROX1 recombinant protein (Position: E51-E737) .

Clonality

Polyclonal

Applications

WB, ICC, IF, IP, Flow Cytometry, ELISA

Field of Research

Adaptive Immunity, Immunology, T Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

References & Citations

1. Dyer, M. A., Livesey, F. J., Cepko, C. L., Oliver, G. Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nature Genet. 34: 53-58, 2003. 2. Harvey, N. L., Srinivasan, R. S., Dillard, M. E., Johnson, N. C., Witte, M. H., Boyd, K., Sleeman, M. W., Oliver, G. Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nature Genet. 37: 1072-1081, 2005. 3. Kazenwadel, J., Michael, M. Z., Harvey, N. L. Prox1 expression is negatively regulated by miR-181 in endothelial cells. Blood 116: 2395-2401, 2010.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

83 kDa

Observed Molecular Weight

90 kDa

Applications Notes

6

Gene Name Synonym

Cholinergic receptor nicotinic alpha 3 subunit

Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

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