Anti-POLA2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
DNA polymerase alpha subunit 2 is an enzyme that in humans is encoded by the POLA2 gene. POLA2 may play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (By similarity) .
Synonyms
Kallistatin; Kallikrein inhibitor; Peptidase inhibitor 4; PI-4; Serpin A4; SERPINA4; KST; PI4
Gene Name
POLA2
Gene ID
23649
UniProt
Q14181
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human POLA2 recombinant protein (Position: N267-P579) .
Clonality
Polyclonal
Tissue Specificity
Expressed by the liver and secreted in plasma.
Applications
Flow Cytometry
Field of Research
Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.
References & Citations
1. Ste Fa N, M. , L Agnès, Thomas, B. , Philippe, D. , Bertrand, G. , & Arnaud, M. , et al. (2009) . Genetic polymorphisms in 85 dna repair genes and bladder cancer risk. Carcinogenesis, 30 (5), 763-768. 2. Beausoleil, S., Villén, J., Gerber, S. et al. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol 24, 1285–1292 (2006) . 3. Stelzl, U. , Worm, U. , Lalowski, M. , Haenig, C. , Brembeck, F. H. , & Goehler, H. , et al. (2005) . A human protein-protein interaction network: a resource for annotating the proteome. Cell, 122 (6), 957-968.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
82457 MW
Applications Notes
6
Gene Name Synonym
Serpin family A member 4
Subcellular Location
Secreted.
Protein Name
Disintegrin and metalloproteinase domain-containing protein 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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