Anti-GATA6 Antibody Picoband® Fluoro488 Conjugated

Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 gene. This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects.

Cancer, Cancer Susceptibility, Epigenetics and Nuclear Signaling, Oncoproteins, Oncoproteins/Suppressors, Proto-Oncogenes, Signal Transduction, Transcription, Transcription Factors

Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.

1. Ho, C. K. M., Wood, J. R., Stewart, D. R., Ewens, K., Ankener, W., Wickenheisser, J., Nelson-Degrave, V., Zhang, Z., Legro, R. S., Dunaif, A., McAllister, J. M., Spielman, R., Strauss, J. F., III. Increased transcription and increased messenger ribonucleic acid (mRNA) stability contribute to increased GATA6 mRNA abundance in polycystic ovary syndrome theca cells. J. Clin. Endocr. Metab. 90: 6596-6602, 2005. 2. Kamnasaran, D., Qian, B., Hawkins, C., Stanford, W. L., Guha, A. GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model. Proc. Nat. Acad. Sci. 104: 8053-8058, 2007. 3. Ketola, I., Toppari, J., Vaskivuo, T., Herva, R., Tapanainen, J. S., Heikinheimo, M. Transcription factor GATA-6, cell proliferation, apoptosis, and apoptosis-related proteins Bcl-2 and Bax in human fetal testis. J. Clin. Endocr. Metab. 88: 1858-1865, 2003.