BT317

BT317 is a blood-brain transmissible mitochondrial Lon peptidase I (LonP1) and CT-L proteasome inhibitor. BT317 can increase the production of reactive oxygen species (ROS) and induce apoptosis in astrocytoma cells. BT317 has antitumor activity[1].

Product Specifications

CAS Number

[38485-94-8]

UNSPSC

12352005

Target

Apoptosis; Proteasome

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bt317.html

Purity

99.81

Solubility

DMF : 2 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=CC=C(C=C1)NC(C2=CC3=CC(Cl)=CC=C3OC2=O)=O

Molecular Formula

C17H12ClNO4

Molecular Weight

329.73

References & Citations

[1]Douglas C, et al. Dual targeting of mitochondrial Lon peptidase 1 and chymotrypsin-like protease by small molecule BT317, as potential therapeutics in malignant astrocytoma. bioRxiv, 2023: 2023.04. 13.536816.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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