Anti-Semaphorin 3B/SEMA3B Antibody Picoband® (monoclonal, 9C4F7) Fluoro488 Conjugated
Product Specifications
Background
Semaphorin-3Bis aproteinthat in humans is encoded by theSEMA3Bgene. It is mapped to 3p21.31. The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis.
Synonyms
T-complex protein 1 subunit gamma; TCP-1-gamma; CCT-gamma; hTRiC5; CCT3; CCTG; TRIC5
Gene Name
SEMA3B
Gene ID
7869
UniProt
Q13214
Host
Mouse
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Semaphorin 3B/SEMA3B recombinant protein (Position: Y55-R624) .
Clonality
Monoclonal
Clone
Clone: 9C4F7
Tissue Specificity
Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
Applications
Flow Cytometry
Field of Research
Chaperones, Protein Trafficking, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
References & Citations
1. Ochi K, Mori T, Toyama Y, Nakamura Y, Arakawa H (2002) . Identification of semaphorin3B as a target of p53. Neoplasia. 4 (1) : 82–7. 2. Tse C, Xiang RH, Bracht T, Naylor SL (January 2002) . Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. Cancer Research. 62 (2) : 542–6.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Chaperonin containing TCP1 subunit 3
Subcellular Location
Cytoplasm.
Isotype
Mouse IgG2b
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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