Anti-Stanniocalcin 1/STC/STC1 Antibody

STC1 (Stanniocalcin 1), also called STC, which is encoded by the STC1 gene. By fluorescence in situ hybridization, Chang et al. (1998) mapped the STC1 gene to chromosome 8p21-p11.2. Wagner et al. (1995) found evidence of STC immunoreactivity in human kidney and serum, suggesting the existence of the hormone in mammals. Zhang et al. (1998) reported a constitutive expression of STC in terminally differentiated neurons. Bell et al. (2001) determined that STC1 was 1 of several transcripts upregulated by umbilical vein endothelial cells during capillary morphogenesis in 3-dimensional collagen matrices.

Interleukin-12 receptor subunit beta-1; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1; IL-12 receptor beta component; CD212; IL12RB1; IL12R, IL12RB

Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. .

1. Bell, S. E., Mavila, A., Salazar, R., Bayless, K. J., Kanagala, S., Maxwell, S. A., Davis, G. E. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. J. Cell Sci. 114: 2755-2773, 2001. 2. Chang, A. C.-M., Jeffrey, K. J., Tokutake, Y., Shimamoto, A., Neumann, A. A., Dunham, M. A., Cha, J., Sugawara, M., Furuichi, Y., Reddel, R. R. Human stanniocalcin (STC) : genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats. Genomics 47: 393-398, 1998. 3. Wagner, G. F., Guiraudon, C. C., Milliken, C., Copp, D. H. Immunological and biological evidence for a stanniocalcin-like hormone in human kidney. Proc. Nat. Acad. Sci. 92: 1871-1875, 1995. 4. Zhang, K., Westberg, J. A., Paetau, A., von Boguslawsky, K., Lindsberg, P., Erlander, M., Guo, H., Su, J., Olsen, H. S., Andersson, L. C. High expression of stanniocalcin in differentiated brain neurons. Am. J. Path. 153: 439-445, 1998.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.